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Acne - Patient's guide
Benzoyl Peroxide
Benzoyl peroxide has been used for acne skin care for over 30 years and is now available in a product that combines it with antibiotics. It is available in different forms including a skin cleanser (especially for your face), cream, gel, and a lotion.
How Do I Use This Medication?
You should apply it daily, initially to dry the skin. Use it in small quantities over all of the affected area.
How Well Does It Work?
It is the most commonly used anti-acne topical medication, and works well for mild to moderate acne. It is available in drying alcohol bases, or in the less drying water bases. It can be effectively combined with a topical antibiotic. The response is slow and takes several months, so you should not expect immediate improvement. It is antibacterial, and also reduces some sebum, resulting in fewer blackheads.
Will There Be Side Effects?
It may irritate your skin producing dryness, redness, and peeling.
To counteract these side effects:
- Use small quantities every other day
- Apply to dry skin (as opposed to wet skin - use your towel)
- Use gentle facial cleansers
- Use light moisturizers
- The product may also bleach hair, and clothing
Can I Take Other Medications?
There are no known drug interactions. However, you should be careful when using this product together with other drying anti-acne medications.
Which Brands Are Available?
- Benzoyl Peroxide - OTC Brands (5% or less)
- BenOxyl® 5%, PanOxyl® Aquagel 2.5% and 5%, PanOxyl® Bar 5%, PanOxyl® 5% Gel, Panoxyl® 5% Wash, PanOxyl® 4% Creamy Wash, Solugel® 4% - Stiefel
- BenzacAC®, BenzacW®, BenzacWwash® - Galderma
- Benzagel® - Novartis
- Clearasil® - Proctor & Gamble
- Dermoxyl® - ICN
- Desquam® - Westwood
- Clean+Clear® - Johnson & Johnson
- Oxy® - Glaxo Smith Kline Beechum
- Acetoxyl® Gel (2.5% and 5%) - Valeo Pharma
Combinations:
- Benzamycin® BP + erythromycin (Dermik)
- BenzaClin® BP + clindamycin (Dermik)
- CLINDOXYL® BP + clindamycin (Stiefel)
What Other Conditions Are Treated By This Medication?
HPB-approved:
Non HPB-approved:
Uses for which this drug has been found to be effective, but which have not been recognized by government regulatory agencies:
- Pressure ulcers and stasis ulcers in some countries
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INTRODUCTION
Clinical experience confirms what has been shown in clinical trials, that Clindoxyl Gel is effective and well tolerated
Once daily application of topical that combines two active anti-acne agents may well increase patient compliance...
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CLININCAL EXPERIENCE
More than six international studies involving over 6,000 patients have shown reductions in the PASI (Psoriasis Area and Severity Index) of approximately 40% after one week of treatment and 70% after four weeks...
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INDICATIONS
Moderate comedonal and papulo-pustular acne
Approved in Canada as a once daily topical for moderate Acne in December 2000...
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PATIENT PROFILE
Any patient who has inflammatory acne can be treated with Clindoxyl Gel
Acne patients with comedones only are best treated by topical retinoids
Patients with cystic acne usually require systemic therapy...
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DOSING
Once daily application of Clindoxyl Gel is recommended
The product needs to be applied to the whole region of skin that is affected with acne. In other words...
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EFFICACY
The following figures show pooled data from randomized, controlled double-blind trials involving 673 patients with acne...
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COMPLIANCE
Three factors to consider for good compliance of Clindoxyl Gel are:
Well tolerated by most patients,
results are often seen within 2 weeks...
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SIDE EFFECTS, SAFETY AND RISKS
Overall tolerance was rated as excellent in 94% of patients.
Potential side effects expected in some patients...
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COST OF TREATMENT
This is a cost effective product.
Reducing inflammation can reduce the risks of scarring...
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View the entire Clindoxyl® Gel presentation.
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INTRODUCTION
There are limitations for regulators, pharmaceutical companies and pharmaceutical sales representatives to present clinical evidence following development of product monograph and drug approval...
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CLININCAL EXPERIENCE
Diane-35® (2mg cyproterone acetate and 0.035mg ethinyl estradiol) is approved for use in Canada to treat women with severe acne who are unresponsive to other available treatments and who have associated symptoms of androgenization, such as seborrhea and mild hirsutism. In addition to treating acne, Diane-35® also provides reliable contraception...
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INDICATIONS
Used to treat women with severe* acne and its associated symptoms of androgenization, including seborrhea and mild hirsutism..
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PATIENT PROFILE
Women who have acne associated or not with signs of hyperandrogenism.
Any woman who has acne that is not controlled with topical medication...
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DOSING
Diane-35® is sold in blister pack units containing 21 tablets.
Each tablet contains 2mg of cyproterone acetate and 0.035mg of ethinyl estradiol. Each cycle consists of 21 days on the medication and a 7-day interval without it...
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EFFICACY
Improvements in seborrhea are generally seen after 2 to 3 months.
Improvements to acne are generally seen after 3 to 4 months.
Numerous studies have proven the efficacy of hormonal therapy in treating acne over 6 or more months of use...
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COMPLIANCE
Patients should take Diane-35® at the same time each day with liquid...
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SIDE EFFECTS, SAFETY AND RISKS
Side effects are typical of most oral contraceptives and can include breast tenderness, headache, nausea, breakthrough bleeding, ankle swelling and weight gain. These side effects are typically mild and tend to resolve by the second or third cycle of therapy...
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COST OF TREATMENT
Diane-35 is sold to pharmacy wholesalers at a cost of $19.00 per cycle...
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View the entire Diane-35® presentation.
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