Fungal Treatment: Understand The Objective and Limitations of Therapy

• INTRODUCTION
  Penlac is the first topical anti-fungal preparation approved specifically for the treatment of onychomycosis. The product was available for use in Canada in...   |   Read more ...



• DRUG
  Ciclopiroxs' mechanism of action is fungicidal by affecting intracellular metabolic processes reducing the organisms ability to process nutrients and detoxify toxic metabolites...   |   Read more ...



• DELIVERY SYSTEM
  Ciclopirox is incorporated into a clear nail lacquer at an 8% concentration which is applied directly onto the nail plate.This transungual delivery system is unique allowing...   |   Read more ...



• PHARMACOKINETICS
  The penetration of ciclopirox through the nail plate is well documented by invitro studies utilizing cow horn and sheep and bovine nailplate. Studies of penetration in human finger and...   |   Read more ...



• APPLICATION TECHNIQUE
  Ciclopirox nail lacquer (Penlac) is applied evenly by brush to the entire nail plate including the undersurface at the distal end and at the sites of onycholysis...   |   Read more ...



• CLINICAL EFFICACY
  The two pivotal US trials were double blind placebo controlled trials involving 549 patients randomized 1:1, placebo:drug who applied ciclopirox daily for 48 weeks to their great toenails...   |   Read more ...



• SAFETY
  The data gathered from clinical trials and post-marketing reports have not shown any significant systemic side effects related to the topical application of Penlac nail lacquer...   |   Read more ...



• PATIENT SELECTION
  In my experience, the patients most likely to have the best experience and be most successful with the use of Penlac are...   |   Read more ...

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